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. The unfolding of this β-sheet allows the water molecules to penetrate into the interior of the catalytic domain, which results in the transformation of some Class I fluorophores to Class II and a further inactivation of the enzyme
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. Conversely, side-chain moves lead to local conformational changes
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. Reference deleted in proof
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. Douglas), University of Colorado at Denver Health Sciences Center; and the Department of Immunology (Dr
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. In the absence of internal motions slower than ~4 ns, (τ^sup o^^sub m^)^sub app-corr^ can thus be considered equal to (τ^sup o^^sub m^)^sub app^, the real overall tumbling time
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. Bound to aggregated TTR, the fluorescence lifetime of both components have increased and the relative amplitude of the slower component has increased (Table 3), well in accordance with the massive increase in quantum yield compared to when bound to native TTR (Fig
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. RESULTSMeasurement of protein-membrane associations under pressurePrevious studies of model membranes underpressure suggest that the primary effect of pressure is in the compressible hydrocarbon region, and the application of pressure increases the gel to liquid crystal phase transition by a constant that depends primarily on the lipid chains (Li and Kay, 1977)
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. For instance, we have shown recently that, under certain conditions, the in vitro amyloidogenesis of insulin closely mimics certain aspects of the strain behavior of prion propagation (Dzwolak et al
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. The main advantage the plant sees is the space savings that will come from reducing the coolant tanks
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. Milk, as secreted, can be predisposed to oxidation
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. 5 Spent Ovary flaccid, purplish- Early-stage oocytesred in color
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. Response variables = AF and RF,treatment factors = year, and covariate = age
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. RESULTSThe base pool of studied cases included 39 epithelial mesotheliomas and 30 cases of reactive mesothelial proliferation, and all of these were tested with EGFR
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. Her postoperative course was uneventful, and she exhibited no evidence of CSF rhinorrhea or other complications on follow-up
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. , 5 are unknown parameters estimated using ordinary least squares (OLS) and [[epsilon]
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. He describes the legislation of drug use and trafficking in France and its tradition of central control, the political and social culture that has led to drug tolerance in The Netherlands, and the restrictive alcohol policies in Sweden that have led to the same in the case of drugs, and how these differences have led to conflict at the international level
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. Wal-Mart weighed in to the supermarket business just a decade ago, through its Supercenter combo stores
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. Copies are also available by download from the APhA website at www
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. The idea behind the personas, says Tom Feitel, Medco's e-commerce vice president, was to synthesize the needs and wants of a large segment of the customer base into a single person
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. H-E-B and CVS also were instrumental in setting up temporary pharmacies at Kelly Air Force Base in San Antonio, another major refugee center for people streaming out of New Orleans and other hard-hit coastal areas
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. "So, the second question: How can he consider poker a sport of any kind, let alone an "amazing sport," when what you do is sit there and
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. " The uncertainty "resulting from funding decisions that are made on a year-to-year basis makes it impossible for stakeholders and service providers to plan over extended periods of time
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. After spending more than $700,000 to lobby for slot machines in the District of Cohimbia, reserving real estate for casinos, and collecting more than 20,000 signatures to conduct a referendum, Black promoters suddenly discovered that the U
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. Temperature scans were performed using a constanttemperature cuvette holder connected to an external constant temperature circulator/bath (F25, Julabo, Seelbach, Germany; using a special Julabo bath fluid H10S)
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. A number of MD simulations have been carried out to shed light on this topic
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.The plots can be interpreted in analogy to Guinier plots of polydisperse dilute solutions: In SAS experiments, linear regimes can be assigned to populations of distinct radii of gyration R^sub g^, provided Q*R^sub g^ Whereas at low temperatures, intensities decreased linearly over the whole Q-range measured for all samples, a more or less pronounced kink appeared in the Guinier plots above ~200 K (Fig
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. For colloidal systems, the initial effects of attraction, particularly at high volume fractions, is a reduction in viscosity as the initial clustering of particles increases the free volume available for structural rearrangement (1)
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. DCVJ has not to our knowledge been used before on an amyloid system but has been employed on microtubule polymerization (Haidekker et al
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. This suggests that the protein refolding detected by CD between 32 and 24°C upon relatively rapid cooling (Fig
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