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. Altering kinetic mechanism and enzyme stability by mutagenesis of the dimer interface of glutathione reductase
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. Blindness in Astyanax seems to be caused instead by mutations in a small number of master switches that control other genes and proteins necessary to the development of the eye
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. The glycosylation accounts for almost 6% (4
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. Standard reference models such as the fully extended chain and the Flory random coil model will grossly underestimate both the diversity and extent of chain-solvent interactions, which in turn leads to a misrepresentation of the extent and type of conformational fluctuations
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. due to simultaneous unfolding between the C- and N-terminal domains
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. A number of MD simulations have been carried out to shed light on this topic
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. Information on the dynamics of protein hydration may be obtained from ^sup 17^O magnetic relaxation dispersion measurements, which indicate that water molecules at protein surfaces are highly mobile (66,67)
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. Taken together, these data indicate that heating of the apoA-2:DMPC disks to 99°C leads to protein unfolding and disk-to-vesicle fusion; consecutive cooling leads to a gradual reduction in the vesicle size and partial protein refolding, followed by formation of smaller protein-containing vesicles and additional helical refolding at 34-24°C
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. Market research clearly shows that Medicare beneficiaries will be looking to their pharmacists as a primary source of information on the new Medicare Prescription Drag Benefit
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. Also, mental component HRQOL scores (MCS-12) for females were significantly lower than those for males
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. Since the folding observed in the SL 4WJ ribozyme construct occurs in the absence of loop-loop interactions, the conformational change must be associated with the 4WJ helical junction element itself
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