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It is provocative and thought provoking as it challenges the established priorities in pharmaceutical research and development, and it is sure to stimulate much-needed discussion and debate of the problems that arise as a new approach to contraception results in the rearranging of social order and gender roles within the family
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Thus, both the appearance of tyrosine emission and the red-shift of tryptophan fluorescence indicated extensive unfolding of GR at 3 M GdnHCl
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If you leave the lights off for a few minutes, you might even begin to "see" how, with patience, you could learn a lot about your surroundings--and perhaps move about (if there are no deep pits nearby!) without the sense of sight at all
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This structure was modeled in SweetII (glycosciences
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Sequence alignments between species were made with CLUSTALW at the EBI svebsile (http://www
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Other MD studies have demonstrated that transient openings in the wall of the gorge, so-called back-doors or side-doors, provide putative alternate routes for traffic of substrate, products, and/or solvent (29,30)
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(9) compared root-mean-square atomic fluctuations of free AChE and of the AChE-huperzine A complex by a 1-ns MD simulation
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This is in agreement with MD simulation data: Modifications in the dynamics of large protein complexes relative to their component subunit are dominated by low-frequency collective modes which take place on the 10-ps range upwards (2,49), and may be invisible in the experimental space-time window chosen
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75 ml g^sup -1^ was then used to obtain the mass of water in the hydrodynamic domain of the protein, and from this the volume fraction of protein at known mass fractions was estimated
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The sample was thereafter stained using 2% uranyl acetate for 20 s, and the grids were dried overnight
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The Θ^sub 222^(t) data recorded in the second and consecutive jumps were similar, indicating faster unfolding than in the first jump (Fig
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The juxtaposed differences between the populations of fibers grown at 60 and 70°C clearly concern not only the rate of the aggregation process, but different quaternary folds as well
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, 2002a) in which the "transition state" strongly constraints the environment of just three residues and the immediate neighbors
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To confirm that our labeled ribozyme constructs are active in cleavage, we performed activity assays using a cleavable all-RNA substrate strand, as described in the Materials and Methods section
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"But it usually would go in the luggage or cargo," he says
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Table 1: Effect of RP on Days of Analgesic Therapy Dispensed per 1,000Seniors over the Post-RP Period, by Analgesic TypeEstimate p-Value95% CIEffect of Type 1 RPNSAIDsAverage monthly effect-1,293
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