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The distributions of distances are sharply peaked for near-neighbor residues and they become increasingly broad as sequence separation increases
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Apoptotic cell calreticulin may also directly engage phagocyte LRP in a trans configuration, thereby bypassing collectin intermediates
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The experiments were carried out on Bruker DRX-400, AMX2-500, and DRX-600 spectrometers equipped with triple-resonance (^sup 1^H/^sup 13^C/^sup 15^N or broadband) probes with XYZ-gradient capabilities
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Before initiation of the aggregation reaction, TTR is in the form of unfolded monomers
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5M ammonium hydroxide (9:7:2, v/v) under nonreducing conditions
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33 K/min is observed above 80°C, ~10°C higher than the onset of the corresponding CD transition
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The increased temperature shortens the lag phase of the aggregation, which is defined as lapse-time passed until the appearance of first fibrillar forms (rather than of transient early amorphous aggregates-see Fig
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