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Our focus in this work is on conformational ensembles accessible to proteins under strongly denaturing conditions
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The far-UV CD spectrum of EI^sup sc^ at neutral pH showed the features of an α-helical protein with minima at 208 and 222 nm (41,42) (Fig
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EI^sup sc^ was a well-folded turner that could be heat-denatured in a single sigmoidal transition, and thus it followed the second mechanism proposed
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Figure 8 exhibits the dependency of wetting force and meniscus height on the perimeter (P) of the substrate
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TTR has been linked to a number of different amyloid diseases, including familial and sporadic ailments (Kelly, 1996)
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Further cooling leads to a steep reduction in the light scattering (and thus in the particle size) between 34 and 24°C
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Effect of denaturant and Chevron plotsAs central a tool to the experimental elucidation of folding kinetics as the protein engineering extraction of Φ-values is the tracking of folding rate with denaturant concentration
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These reproductive grounds are consistent with the principal areas of summer concentration described by Otero et al
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[FIGURE 4 OMITTED]Pharmacare savings from RP might also be mitigated by increased spending on more costly analgesics, such as opiates, which cost Pharmacare about $1 per day of therapy prior to the introduction of Type 1 RP (Table 2)
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