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. Structures of product and inhibitor complexes of Streptomyces griseus protease A at 1
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. This novel mode of target-specific binding, which neither belongs to lock-and-key nor induced-fit binding, is characterized by dimerization and continuous exchange between multiple flexible binding alternatives
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. In this case the particle motions become constrained in cages and the particles can no longer diffuse freely
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. After 2 h, only very small aggregates (400 h), the protofibrils have increased in length to 100-200 nm, and the spherical clusters have decreased in size to 20-30 nm in diameter (Fig
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. The majority of mature amyloids are unbranched fibrils (Rochet and Lansbury, 2000) consisting of several, often intertwined protofilaments (which may form an internal waterfilled canal-Perutz et al
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. Characterization of the oligomeric states of insulin in self-assembly and amyloid fibril formation by mass spectrometry
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. When the mutation of a residue gives rise to a value of Φ close to 1, it means that the change in folding rate arising from the mutation is consistent with comparable changes in the transition state and native state energies
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