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Lane, like others, has grown cynical about the council system, saying he rarely goes to meetings and, like many New England fishermen, is considering getting out of the business
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In the final structure, the interface domain is hidden in a hydrophobic, packed core surrounded by the other domains, as demonstrated by crystallographic studies of human GR (Schulz et al
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The dielectric spectra of protein aqueous solution have usually manifest at least three relaxation processes called delta, and gamma (Grant et al
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We observe that the unfolding of gSBA is a two-state process
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As a consequence, the EV limit is characterized by hierarchical contacts whereby the distribution of distances between near-neighbor residues is narrow and peaked around smaller values
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However, there are examples of homologous proteins that unfold following different patterns and, in addition, have different thermodynamical parameters (60,61)
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This is based on the observations that the bound SEF2-lmp lacks any well-defined conformation, and that not all hydrophobic peptide residues simultaneously interact with the hydrophobic patches on the inner surface of the CaM dimer (11)
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Fluorescence characterization of different protein conformersThe A-state of TTR binds the classic hydrophobic dye ANS (Lai et al
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For example, the apparent melting temperatures inferred from the CD data recorded at 80 K/h are T^sub m,A-1^ = 91°C, T^sub m,A-2^ = 84°C, and T^sub m,C-1^ = 72°C
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It could be argued that cheese eaten on a regular basis adds balance to the diet and, hence, normality to our physiology
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Canadian Journal of Zoology 60:1282-1288
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The larvae enter the bite wound and migrate through the tissue of the animal, where they grow into adult worms that live in the arteries of the lungs and in the right side of the heart
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"We will also be offering the program to retail pharmacies in the 22 states with an 'any willing provider' statute," said Dan Ramirez, Rx
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8%), and other games of skill (7
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Matriarch loved family, blackjack Mary Lou Martin showered each of her 14 grandchildren and five great-grandchildren with affection -- so much so that all were convinced she loved them best, family members said
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. Recently, the crystal structure of a D-aminoacylase from Alcaligenes faecalis was determined (16)
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. Do harshly denaturing environments such as 8 M urea or 6 M GdnCl mimic perfect solvents? In previous work, we developed a fast and accurate way to generate thermal, self-avoiding distributions for proteins with atomistic detail (48)
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. Alveolar macrophages that phagocytose apoptotic neutrophils produce hepatocyte growth factor during bacterial pneumonia in mice
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. As a consequence the observed emission spectra of individual proteins (and of their corresponding conformational states) do not even vary with respect to λ^sub max^ but also can show different spectral shapes and widths (7,8)
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. Indeed, if one compares liquid and frozen state profiles at the same effective ANS concentration in the liquid phase (bulk solution versus liquid water pools formed at intergranular spaces), we see that strong ANS binding is largely abolished in ice
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.It is widely accepted that pico- to nanosecond thermal fluctuations serve as a lubricant for functionally relevant motions occurring on a micro- to millisecond timescale (6)
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. In the solutions containing 100 mM NaCl and 10 mM acetate buffer alone, this interaction becomes increasingly attractive at short range
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. The C^sub p^(T) data indicate a gradual reduction in the vesicle population and a concomitant increase in the disks population during incubation (Fig
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. Each has advantages and drawbacks, but it is not clear whether each applies to a restricted subset of real cases, or whether all might have something to say about the folding of any one protein
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. Preformed units of secondary structure diffuse hydrodynamically and merge
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.CONSEQUENCES OF HIGH-DIMENSIONAL SEARCHESWe have identified two general predictions of this high-dimensional view of folding: 1), the sequential diffusive exploration of low-dimensional subspaces favored by fast folding; and 2), the suggestive stabilization of these subspaces by discriminate but nonnative (or near-native) interactions, without recourse to long-range guiding forces
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. The topomer search model: a quantitative, first-principles description of two-state protein folding kinetics
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. The premaxilla was an elongated bone with three processes on its dorsal margin--the first one perpendicular to the premaxilla
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