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Commercial fishing is a deeply troubled industry, caught between a freebooting past in which high seas fishing was a free-for-all among fishermen who behaved as if the fish in the sea were inexhaustible--and a future in which fish populations are known to be finite, with many threatened or even facing extinction
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* There were previous, concurrent, or subsequent transactions involving the subject property or the borrower
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The FutureRisk managers generally agree that the biggest risk to an organization is the risk you don't know about
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Using a nest of nonprofits flush with corporate cash, the discredited lobbyists played a vital, albeit hidden, role in whittling down congressional opposition to the bill for more than a year before the final vote
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Despite the large amounts of ACYI that exist in mammalian kidney and liver, the reactivation of ACYI is particularly difficult in vitro (19-21), which suggests that the folding of ACYI in vivo might be assisted by the possible intracellular molecular chaperones and/or osmolytes
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Phase diagram analysis of IR and fluorescence data The phase diagram analysis, which is a sensitive tool to detect folding intermediates, was carried out as described previously (35)
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However, on increasing the denaturant concentration further, to 3
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The distortion of the native structure inferred from ANS binding was found to draw a parallel with the extent of irreversible denaturation by freeze-thawing, suggesting that these altered conformations play a direct role on freeze damage
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A stressed condition of the native structure in ice appears to be common to most proteins even if oligomers seem to be more susceptible than monomers presumably because the globular fold can be further destabilized by subunit dissociation
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Disk fusion is accompanied by dissociation of lipid-poor monomolecular apoA-2, as indicated by the low-molecular-weight band corresponding to the particle size of ~7
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, 2003a; Fang et al
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Moreover, as the phenomenon of protein aggregation appears to reflect certain generic polymeric features of proteins (Fandrich and Dobson, 2002), studying mechanisms of protein aggregation on model systems is extremely useful for a better understanding of the molecular mechanisms of disease-associated amyloidogenesis
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Methodological issues in lipid bilayer simulations
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"If Mayor Albano continues with his program in Springfield and convinces other towns to join, the safety of the medication system will be further challenged, and more problems will arise than it will resolve," he added
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